The Next Generation of
Covalent Inhibitors

A biopharmaceutical company developing covalent inhibitors with novel chemistry and an AI-enabled chemoproteomic discovery platform with a mission to develope therapies for high-unmet medical needs.

Explore the science

Thyora Therapeutics aims to unlock disease-relevant proteins beyond the reach of conventional drug discovery and accelerate the development of next generation covalent therapies with greater precision and safer clinical profiles. Thyora expands the druggable proteome by using Covalogic, in-house AI-enabled chemoproteomic platform, and novel covalent warheads to identify and engage previously inaccessible targets in cancer, neurological, and immune disorders.

Our Science

Targeted covalent modulation, by design

Covalent drugs bind their target and then, traditionally, form an irreversible chemical bond. Thyora's platform pairs novel warhead chemistry with the potential for greater potency, higher specificity, and lower systemic exposure.

Diagram: a covalent drug forms a directed covalent bond with its protein target via a low-reactivity covalent reactive group.

Therapeutic Focus

Cancer

Precision covalent therapeutics for oncology targets.

Neuro

Addressing targets in neurological disorders.

Immune

Modulating drivers of immune disease.

Our People

Founders & Leadership

Timothy Langer
Timothy LangerChief Executive Officer
Derek Duckett, Ph.D.
Derek Duckett, Ph.D.Co-Founder
Andrii Monastyrskyi, Ph.D.
Andrii Monastyrskyi, Ph.D.Co-Founder
Justin Lopchuk, Ph.D.
Justin Lopchuk, Ph.D.Co-Founder

Advisors

Phil Baran, Ph.D.
Phil Baran, Ph.D.Scientific Advisor

Leads the Baran Laboratory at Scripps Research and co-founder of Vividion Therapeutics.

Mace Rothenberg, M.D.
Mace Rothenberg, M.D.Clinical Advisor

Former Chief Medical Officer at Pfizer, with 13 years leading oncology clinical development.

Nicholas Meanwell, Ph.D.
Nicholas Meanwell, Ph.D.Scientific Advisor

40 years leading drug discovery in cardiovascular, neuroscience, and viral therapeutics at BMS.

Partners

Advancing our science alongside leading institutions.

News

Coming soon!